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Postdoctoral Fellow positions in Genetics/Genomics and Neuroimmunology of Alzheimer's Disease

Goate Laboratory

Postdoctoral Fellow positions in Genetics/Genomics and Neuroimmunology of Alzheimer's Disease

New York, NY
Full Time
Paid
  • Responsibilities

    AVAILABILITY

    Immediately available, NIH funded

    DESCRIPTION

    To fulfill the mission of the Ronald M. Loeb Center for Alzheimer's Disease, Drs. Alison Goate and Edoardo Marcora (in the Departments of Genetics and Genomic Sciences and Neuroscience at the Icahn School of Medicine at Mount Sinai in New York City) are searching for highly skilled, creative and motivated postdoctoral scientists with diverse experiences and interests in genetics, genomics, microglia biology and neuroimmunology to join an interdisciplinary team and be the drivers of our efforts to translate genetic discoveries into testable therapeutic hypotheses and early stage drug development efforts for Alzheimer's disease (AD).

    Candidates will join a multidisciplinary and highly collaborative research team that includes geneticists, computational biologists, immunologists, neuroscientists, and physician-scientists, as well as at other collaborating leading US and European academic institutions and biopharmaceutical companies.

    WE HAVE TWO OPEN POSITIONS! One with a focus on computational approaches and genetics and genomics of AD, and the other with a focus on experimental approaches and microglia biology and neuroimmunology of AD.

    COMPUTATIONAL BIOLOGIST

    We are looking for a statistical geneticist, genetic epidemiologist, biostatistician or bioinformatician/computational biologist with experience in analyzing and interpreting human genetic data in association with complex disease and disease-associated molecular and cellular traits that are relevant to disease pathogenesis (e.g., eQTLs and epigenomic annotations, clinical data, bulk and single cell transcriptomic signatures and/or cellular phenotypes from genetic or drug perturbation screens, etc). The position will involve collaboration with dry- and wet-lab biologists to generate new mechanistic insights in disease etiology and progression, and translation to therapeutic strategies.

    Qualifications and Skills

    • Ph.D. in statistical genetics, genetic epidemiology, biostatistics, or bioinformatics/computational biology
    • Statistical programming skills (R)
    • Programming/Scripting skills (Python/Shell/Others)
    • Knowledge of computing in a cluster environment
    • Knowledge of study design
    • Strong research experience in large-scale genome-wide association analysis (GWAS) of common and rare variants (both NGS and chip-based genotype data)
    • Strong research experience in analysis of large-scale genomic datasets (RNA-Seq, ChIP-Seq, ATAC-Seq, HiC, etc)
    • Strong research experience in post-GWAS analysis (e.g., locus-to-gene mapping and fine-mapping) by integration of genomic datasets
    • Strong research experience in Mendelian Randomization and/or Polygenic Risk Scores (preferred)
      • or - Strong research experience in single-cell genomic data analysis (preferred)
    • Self-motivated and highly dedicated
    • Effective organizational and prioritization skills
    • Effective oral, written, and interpersonal communication skills
    • Ability to work both independently as well as collaboratively in a multidisciplinary environment

    EXPERIMENTAL BIOLOGIST

    We are looking for a molecular and cell biologist with experience in translating genetics and human biology observations into in vitro (induced pluripotent stem cell models) and/or in vivo systems (mouse models) to understand innate immune modifiers of AD pathogenesis. In particular, the Goate lab concentrates on identifying human genetic variants associated with AD and dissecting the molecular, cellular and tissue-level mechanisms by which these variants and the associated genes (e.g., APOE, TREM2, SPI1/PU.1, MEF2C, MS4A) modulate disease risk, with a major focus on the role of microglial cell function (e.g., phagocytic clearance of cholesterol-rich cellular debris) in the maintenance of brain tissue homeostasis during aging and in disease conditions.

    Qualifications and Skills

    • Ph.D. in Biology, Neuroscience, Immunology, or related field with deep expertise in molecular and cellular biology techniques
    • Strong research experience in microglia/macrophage biology (preferred)
    • Strong research experience in mouse microglia/macrophage biology in vivo (preferred)
      • or - Strong research experience in human iPSC technology and targeted genome editing in vitro (preferred)
      • or - Strong research experience in high-throughput technologies (e.g., NGS and CyTOF) for bulk and single-cell transcriptomics, epigenomics, lipidomics and/or proteomics (preferred)
      • or - Strong research experience in functional genomics (e.g., siRNA, shRNA, CRISPR/Cas9, and chemogenomic) screens (preferred)
    • Knowledge of experimental design
    • Statistical and quantitative analysis skills
    • Basic bioinformatics skills (preferred)
    • Self-motivated and highly dedicated
    • Effective organizational and prioritization skills
    • Effective oral, written, and interpersonal communication skills
    • Ability to work both independently as well as collaboratively in a multidisciplinary environment

    STRENGTH THROUGH DIVERSITY

    The Mount Sinai Health System believes that diversity and inclusion is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet we're as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Mount Sinai's unrivaled record of achievement, education and advancement as we revolutionize healthcare delivery together.

    We work hard to recruit and retain the best people, and to create a welcoming, nurturing work environment where you have the opportunity and support to develop professionally. We share the belief that all employees, regardless of job title or expertise, have an impact on quality patient care.

    Explore more about this opportunity and how you can help us write a new chapter in our story! 

    The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression.