The scientist III will be part of the San Diego R&D group to execute key innovation projects for driving excellence and quality in drug discovery services.

The San Diego R&D group is responsible for the development of novel biochemical assays using proprietary KINOMEscan platform to measure active site-directed competition binding for diverse target classes, including kinases, bromo-domain proteins, and E3 ligases. In addition, the R&D group is developing novel biochemical technologies to expand capabilities in the Targeted Protein Degradation drug discovery space.

RESPONSIBILITIES

• Perform cloning and characterization of engineered cell lines using molecular and cell biology techniques, including flow cytometry, qPCR, Western blotting, immunofluorescence, EFC or other functional readouts
  
• Perform required experiments to optimize and validate diverse cell-based assays intended for sale in our product portfolio or as custom projects for clients with minimal guidance from supervisor
  
• Perform proof-of-concept experiments to validate application of new molecular technologies to the platform
  
• Perform testing of cell-based assays using technology platforms with client molecules and record results in company database
  
• Prepare and present experimental data at group laboratory meetings
  
• Work diligently to meet product development goals set by management team· Provide support functions to the R&D team such as ordering and maintaining reagents/supplies/equipment, maintaining accurate notes and records, and effective communication with other departments
  
• Demonstrates and promotes the company vision
  
• Regular attendance and punctuality
  
• Applies GMP/GLP in all areas of responsibility, as appropriate
  
• Conducts all activities in a safe and efficient manner
  
• Performs other duties as assigned
  
• Owns the accountability and responsibility of delivering to client needs and timeliness
  
• Provides cross-functional support to other departments as required
  
• Adjusts work hours as needed to meet client deadlines
  
• Adheres to site environmental health and safety (EHS) requirements

QUALIFICATIONS

The Ideal Candidate would possess:

• Experience working with direct binding methods, including at least one of the following: MST, DSF, SPR, or ITC, is a plus.
• Skilled in biochemical assay design, execution, analysis, and troubleshooting preferably in a screening environment.
• Independent execution of standard cloning and molecular biology projects, including DNA sequence QC, and protein extraction.
• Ability to follow SOPs to the letter without deviating from the protocol.
• Highly organized, efficient and able to multitask.
• Outstanding oral and written communication skills, including laboratory notebook policy adherence and power point presentations.

Basic Minimum Qualifications:

• B.Sc. in biophysics or biochemistry and at least 7 years of relevant experience or PhD with no experience. Deep understanding of ligand binding kinetics and thermodynamics, including supporting equations and assumptions.
• Experience performing, analyzing, and designing routine, innovative, and troubleshooting experiments for quantitative biochemical and /or biophysical assays
• Experience working in a molecular biology lab executing routine cloning, DNA sequence analysis and protein extraction projects
• Superior computer and computational skills required (Excel and Graphpad).
• Authorization to work in the United States indefinitely without restriction or sponsorship