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Immunoassay Development Scientist - Analyte Detection

Eurofins USA Discovery Services

Immunoassay Development Scientist - Analyte Detection

Fremont, CA
Full Time
Paid
  • Responsibilities

    Job Description

    We are seeking for hands-on immunoassay developers for a new Analyte Detection Business Unit. If you have designed assays from scratch, selected and screened reagent pairs, and solved real development problems across ELISA, MSD, TR-FRET, AlphaLISA, or related formats, we want to hear from you. Here’s what you’ll do:

    _ Laboratory Execution & Technical Support_

    • Design and execute bioconjugation strategies for labeling antibodies and other proteins with donor/acceptor fluorophores (NHS-ester, maleimide, and related chemistries); optimize reaction conditions, purification, and labeling efficiency from first principles
    • Develop homogeneous immunoassays (TR-FRET, HTRF, AlphaLISA, MSD, and/or ELISA) for analyte detection; own the full development cycle from reagent selection and antibody pairing through format optimization and matrix validation
    • Lead independent antibody screening campaigns to identify optimal capture/detection pairs; apply structured DOE approaches to optimize reagent concentrations, buffer formulations, and assay window
    • Conduct routine assay validation experiments, including precision, accuracy, linearity, and range determination
    • Prepare biological samples, reagents, and buffers according to SOPs
    • Operate and maintain laboratory equipment, including plate readers, liquid handlers, and analytical instruments
    • Independently diagnose and resolve assay performance failures; apply root-cause analysis to reagent, buffer, and instrument variables and propose data-driven corrective actions
    • Support antibody screening and characterization activities
    • Assist with benchmarking studies comparing assay performance to competitor products

    _ Data Management & Documentation_

    • Maintain detailed, accurate, and organized laboratory notebooks documenting all experimental procedures and observations
    • Analyze experimental data using GraphPad Prism, Excel, or similar software
    • Generate clear data summaries, graphs, and tables for internal reports and presentations
    • Contribute to technical reports and validation documents
    • Assist in drafting sections of SOPs and user manual protocols
    • Ensure all documentation meets company quality standards and regulatory requirements

    _ Collaboration & Learning_

    • Work collaboratively with Senior Scientist and other team members to support project timelines
    • Participate in team meetings and provide updates on experimental progress
    • Communicate experimental results and technical challenges effectively to the supervisor
    • Actively seek learning opportunities to develop technical skills in bioconjugation and immunoassay development
    • Support cross-functional activities with Manufacturing, Quality, and Marketing teams as needed
    • Participate in training programs to enhance scientific and professional development

    _ Compliance & Safety_

    • Adhere to all site employee health and safety (EHS) and IT security requirements
    • Demonstrate and promote the company vision and values
    • Maintain regular attendance and punctuality
    • Conduct all activities in a safe and efficient manner
    • Perform other duties as assigned
    • Meet project deadlines and adjust work hours as needed to support team objectives
  • Qualifications

    Qualifications

    Here is who and what we are are looking for in the ideal candidate:

    _ Education/Experience (BMQ)_

    • BS/MS in chemistry, biochemistry, biology, or related discipline with 3–7 years of hands-on industrial experience developing immunoassays from scratch (ELISA, MSD, TR-FRET/HTRF, AlphaLISA, or equivalent); experience must include reagent selection, antibody screening, and quantitative assay optimization — not solely protocol execution
    • Demonstrated experience independently developing and validating immunoassays — including reagent pair selection, signal-to-noise optimization, and characterization studies — with a verifiable track record of assays taken from concept to validated format
    • Solid understanding of antibody-antigen binding kinetics, epitope considerations for sandwich vs. competitive immunoassay design, and the impact of protein biochemistry on assay performance
    • Familiarity with aseptic technique and cell culture is a plus

    _ Ability and/or Skills (BMQ)_

    • Strong laboratory skills with attention to detail and accuracy
    • Basic proficiency in data analysis using Excel; familiarity with GraphPad Prism or similar software is a plus
    • Good organizational and time management skills with the ability to balance multiple tasks
    • Ability to design experiments from first principles, generate and test hypotheses, and translate results into actionable next steps — not limited to following pre-written protocols
    • Strong work ethic with demonstrated reliability and accountability
    • Eagerness to learn new techniques and acquire new scientific knowledge
    • Good verbal and written communication skills
    • Team player with positive attitude and willingness to collaborate
    • Ability to work independently on assigned tasks while knowing when to seek guidance
    • Comfortable working in a fast-paced laboratory environment with defined deadlines

    _ Additional Preferences_

    • Experience developing assays in two or more immunoassay platforms (e.g., ELISA, MSD/ECL, TR-FRET/HTRF, AlphaLISA, Luminex); cross-platform familiarity is a strong differentiator
    • Hands-on bioconjugation experience beyond kit use: NHS-ester, maleimide, aldehyde, or click-chemistry conjugation of small molecules, haptens, or fluorophores to antibodies or proteins, including optimization of degree of labeling (DOL) and purification
    • Hands-on experience with multi-channel pipettes, automated liquid handlers, and plate readers
    • Familiarity with time-resolved fluorescence or FRET-based detection principles (TR-FRET/HTRF, LANCE, or AlphaLISA); experience with plate reader instrumentation for fluorescence or luminescence readouts (e.g., PHERAstar, EnVision, or equivalent)
    • Academic or industrial research experience in drug discovery, diagnostics, or related areas
    • Experience maintaining detailed laboratory notebooks and documentation
    • Applied experience with Design of Experiments (DOE) for reagent concentration and buffer optimization, not merely theoretical familiarity
    • Experience presenting research findings in laboratory meetings or scientific conferences
    • Demonstrated problem-solving skills and scientific curiosity
    • Proficiency with Microsoft Office Suite (Word, Excel, PowerPoint)

    Additional Information

    Salary Range: $95,000 - $125,000/yr.

    • Excellent full time benefits including comprehensive medical coverage, dental, and vision options
    • Life and disability insurance
    • 401(k) with company match
    • Paid vacation and holidays

    Eurofins USA Discovery Services is a Disabled and Veteran Equal Employment Opportunity employer.

  • Compensation
    $95,000-$95,000 per year