At Metrum Research Group, we are driven to improve health and defeat disease, especially where there are unmet needs. We work at the intersection of data, science, and technology to generate insights that transform biomedical decision making.

We are seeking a Principal Scientist and Group Leader, PKPD Modeling and Simulation who is passionate about advancing model informed drug development and mentoring the next generation of scientists. If you are energized by scientific excellence, collaboration, and sharing knowledge openly with the community, we would love to connect.

The Role

This position combines scientific leadership, client engagement, and people development. You will lead a team of modeling and simulation scientists while also serving as a Project Leader on client engagements. You will shape pharmacometric strategy, guide quantitative decision making, and contribute to the broader scientific community through publication and presentation.

This role may be hired at the Principal Scientist I or II level based on experience and demonstrated leadership impact.

What You Will Do

• Lead and mentor a group of PKPD modeling and simulation scientists
• Support the professional growth and scientific development of team members
• Design and implement quantitative, data driven pharmacometric strategies to guide drug development programs
• Perform and oversee modeling and simulation analyses supporting clinical trials and regulatory strategy
• Provide strategic drug development consultation and technical guidance to clients
• Contribute to business development through project scoping and proposal preparation
• Prepare and deliver reports and presentations for internal and external audiences
• Present and publish scientific findings
• Participate in company training initiatives as an instructor or contributor
• Advance the scientific and strategic goals of the organization

What You Bring

• PhD in pharmaceutical sciences, pharmacokinetics, mathematics, statistics, biomedical engineering, or a related discipline, or a Master's degree with substantial relevant experience
• 8+ years of postgraduate experience in modeling and simulation
• Demonstrated experience leading individuals or teams
• Strong mentoring and coaching skills
• Deep expertise in PKPD and pharmacometrics within drug development
• Proficiency in tools such as NONMEM, MONOLIX, STAN
• Experience with R, SAS, or similar statistical programming platforms
• Experience with Bayesian data analysis
• Excellent written and verbal communication skills
• Ability to collaborate effectively across multidisciplinary teams

Why MetrumRG

We believe our success depends on the well being and growth of our team. We are committed to creating a work life that is engaging, rewarding, and meaningful. Our culture values continuous learning, scientific rigor, collaboration, and open sharing of knowledge.

We offer competitive compensation and a comprehensive benefits package.

If you are ready to lead, mentor, and advance the science of pharmacometrics in partnership with innovative biomedical organizations, we encourage you to apply.

Metrum Research Group EEO Statement

MetrumRG believes that innovation is cultivated when we challenge each other with new ideas and perspectives. MetrumRG is an equal opportunity employer that is committed to building a diverse and inclusive team. All employment decisions are based on qualifications, merit, and business needs, and we prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, gender identity, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.

MetrumRG is committed to providing equal employment opportunities and reasonable accommodations for candidates and employees with disabilities. We encourage all qualified candidates to apply for positions within our organization. If you require reasonable accommodation because of a medical condition for the application or interview process, please contact Scotti Rylands or our Talent and Culture Department, (860)735-7043 x-622, or message us and we will work with you to meet your needs.