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Janssen Research and Development, L.L.C., a member of Johnson and Johnson's Family of Companies, is recruiting for a Postdoctoral Fellow, to be located in San Diego, CA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

The ImmunoDermatology group in the Immunology Translational Sciences department is searching for a highly motivated, creative and collaborative postdoctoral fellow to advance our understanding of IL-23 biology in health and disease. This is an exciting opportunity to investigate the role of IL-23 producing cells using patient specimens. The postdoctoral fellow will be skillful in crafting in vitro and ex vivo functional characterization of human dendritic cells by flow cytometry, immunofluorescence and transcriptional analysis. They will analyze clinical trial samples to investigate the pharmacodynamic response to guselkumab, an IL-23 inhibitor. The successful candidate will engage in the planning, execution, and interpretation of laboratory experiments, such as assay optimization and development, data collection, data QC and data analysis. They will be conducting experiments with limited guidance and will be encouraged to collaborate with bioinformaticians and lab scientists to conduct multi-omic analysis. The candidate will also evaluate and optimize method for novel platforms to enable multiparameter analysis of patient derived samples. This will be an opportunity for career development and growth and potential publications.

RESPONSIBILITIES ARE AS FOLLOWS:

• Crafting, performing and interpreting ex vivo experiments with primary human tissue and immune cells isolated from biopsy tissue or blood.

• Using various molecular biology approaches, including Nanostring, single cell RNAseq, multiplex immunofluorescence, tissue spatial transcriptomic, to generate proteomic and transcriptomic data.

• Demonstrating independent problem solving and systematic data-driven experimental design and execution.

• Crafting and applying flow cytometry to immunophenotype cell populations using multicolor panels in various platforms and analyzing the data generated.

• Assessing new technologies/platforms that may be applied in current/future biomarker studies.

• Providing project update and experimental findings in oral and written communication.

• Authoring conference abstracts and peer-review publications.

QUALIFICATIONS

• PhD in Immunology with background in dendritic cell biology required.

• Experience with human cell tissue culture, multiplex immunofluorescence and flow cytometry is required.

• Ability to ask impactful scientific questions and address them using a range of techniques (flow cytometry, scRNAseq, immunofluorescence, primary cell culture).

• Experience with spatial transcriptomic is preferred.

• Excellent organization, communication, presentation skills and scientific/technical writing skills.

• Dynamic entrepreneurial attitude.

At Johnson & Johnson, we’re on a mission to change the trajectory of health for humanity. That starts by creating the world’s healthiest workforce. Through cutting-edge programs and policies, we empower the physical, mental, emotional and financial health of our employees and the ones they love. As such, candidates offered employment must show proof of COVID-19 vaccination or secure an approved accommodation prior to the commencement of employment to support the well-being of our employees, their families and the communities in which we live and work.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.

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