SBP is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease, and advancing scientific discoveries to profoundly impact human health. For over 40 years, our research has produced breakthroughs in cancer, neuroscience, immunology and children’s diseases, and is anchored by our NCI-designated cancer center and advanced drug discovery capabilities.

SUMMARY

A postdoctoral associate opening is available in the laboratory of Alexey Terskikh lab at the Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.  The Terskikh laboratory is thriving is at the intersection of neurogenesis, cancer, and epigenetics. We have established mouse models of adult neurogenesis using conditional ablation of SOX2 and primary cilia (Shh signaling) in radial glia stem cells and developed a novel platform for microscopic imaging of epigenetic landscape (MIEL) in single cells. MIEL uses advanced imaging and machine learning to investigate the change of epigenetic signatures during cell differentiation and upon exposure to the environment, including the high throughput drug screening format.

A successful candidate will develop his/her own project while supporting several ongoing projects in the laboratory through automating information and analysis pipelines, data integration, pattern-matching analyses and visualization of a variety of different data sets, including single cell sequencing, bulk NGS, ChIP-Seq, Nuc-Seq, ATAC-Seq, and proteomics.

TO APPLY: Interested candidates should apply online to the SBP career site by submitting one PDF document with a cover letter, CV, references and list of any publications or accomplishments. 

Duties and Responsibilities

• Utilize high-throughput datasets (ChIP-Seq, single cell RNA-seq, proteomics) collected from cellular and animal models to discover networks and pathways and to generate predictions and hypotheses.
• Independently design and perform experiments with high degree of complexity, demonstrating progressively increasing expertise with a wide range of techniques.
• Support ongoing projects and contribute to the general technical knowledge of the laboratory
• Write reports, manuscripts, and application for funding with increasing responsibility over time
• Work collaboratively across lab functions and train other junior lab staff as needed.

Required Skills Required Experience

• Ph.D. degree in Bioinformatics or Biological Sciences (such as Computer Science, Bioinformatics, Biostatistics, Life Sciences) is required
• Emphasis on bioinformatics and relevance to human disease is preferred
• The candididates should demonstrate strong ability in bioinformatics, systems biology, sequence analyses, network analyses or genetics including expertise in high-throughput data analyses, such as RNA-Seq, single cell RNA-seq, differential gene expression analyses, gene co-expression analyses (e.g. Cytoscape, IPA, WGCNA, NextBio)
• Strong programming skills (Python, R, Java or C++ ) is required
• Familiarity with algorithms and tools, such as Bowtie, cufflinks, BWA, STAR, RSEM, UCSC Genome Browser, samtools, bedtools, vcf-tools etc.
• Knowledge of machine learning approaches is a plus

Other Knowledge, Skills and/or Abilities

• The ability to work independently and to handle multiple projects and deadlines
• Demonstrated ability to work in an interactive and collaborative team
• Excellent presentation, verbal, and written communication skills
• Possess strong attention to detail, analytical, time management, organizational, and interpersonal skills
• Embody the Institute's core values of Commitment, Collaboration, Communication, Community and Compassion

Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity employer – M/F/Veteran/Disability – committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law. For additional information about your rights as an applicant, click HERE.

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• • Must have a strong attention to detail and be comfortable working independently and with a team
    • Must be able to understand both written and verbal instructions
    • Must be able to work overtime as needed
    • Must be able to stand for 8 hours a day
    • Must be able to lift up to 45 pounds frequently
    • Must be able to bend, reach and turn frequently
    • Accurate counting and basic math skills
    • Strong attention to detail