Job Description

We are seeking an innovative Scientist to join our growing Preclinical Development team! This position is ideal for recent Ph.D. graduates who are interested in pursuing a career in industry instead of pursing a Postdoc. As a Scientist, in vivo Pharmacology, you will collaborate closely with the preclincal leadership team to develop and execute studies focused on evaluating the safety and efficacy of our lead therapeutic candidates in animal models of cardiomyopathy and age-related disorders. This role will involve leading certain projects and working with internal team members, external collaborators, and CROs. The successful candidate will possess expertise in protein and DNA assay development (e.g., ELISA, Western Blot, qPCR) and mammalian cell culture, as well as exceptional data management and integrity skills. This position reports to the Sr. Scientist of our Pharmacology group.

RESPONSIBILITIES:

• Carry out screening of in vivo generated samples to evaluate safety, efficacy, and optimization of novel AAV-based therapies in animal models of cardiomyopathy, metabolic disorders, and age-related disease.
• Performing basic and advanced cell culture on a variety of cell lines. 
• Majority of time dedicated to performing experiments in the lab.
• Designing and executing experiments independently and in conjunction with cross-functional assay and product development teams in support multiple gene therapy programs. 
• Assist in the preparation of study reports for IND enabling studies for late-stage gene therapy candidates. 
• Foster cross-functional collaborations with academic institutions and CROs.
• Adhere to laboratory protocols and safety regulations.
• Meticulously document all experiments and laboratory practices.
• Deliver on-time, high-quality results and effectively communicate progress clearly in group meetings.
• Perform any additional duties assigned by supervisor or manager.

Qualifications

• Ph.D. in Biology, Biochemistry, Pharmacology, Physiology, or related discipline. Postdoc or industry experience is not required. We specifically seek a highly motivated recent Ph.D. graduate who wishes to forgo a postdoc and launch their career in industry. 
• Knowledge and experience with viral vectors and in vivo delivery of AAV is highly preferred.
• Demonstrated experience leading projects to completion and experience leading in vivo pharmacology and/or toxicology projects is highly desirable.
• Experience with DNA and protein-based assay development (ex. ELISA, Western Blot, qPCR) is a must.
• A knowledge of statistical analysis and data visualization software for large preclinical datasets.
• Demonstrable experience keeping pristine records of experiments and DNA constructs produced using a digital laboratory notebook.
• Ability to successfully do research independently with only a goal as input. 
• Excellent communication and interpersonal skills, with a demonstrated ability to work cross-functionally.

Additional Information

BASE SALARY: $100k - $120k+; exact salary and job title will depend on experience.

PHYSICAL REQUIREMENTS: The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

• Position is primarily sedentary, and employee may be required to sit for extended periods of time.
• Standing, walking and meeting activities are required frequently throughout the workday.
• Must be able to process paperwork and utilize office equipment (including personal computer, phone, copiers, etc.).
• Normal sight or corrected vision is required to read documents and use standard computer terminals. Some light lifting may be occasionally required.
• Ability to safely and successfully perform the essential job functions consistent with the ADA, FMLA and other federal, state and local standards, including meeting qualitative and/or quantitative productivity standards.
• Ability to maintain regular, punctual attendance consistent with the ADA, FMLA and other federal, state and local standards
• Must be able to lift and carry up to 25 lbs
• Must be able to talk, listen and speak clearly on telephone

EEO STATEMENT Rejuvenate Bio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Rejuvenate Bio is an E-Verify Employer in the United States. All your information will be kept confidential according to EEO guidelines.

THE HEALTH AND SAFETY OF OUR EMPLOYEES AND THEIR FAMILIES IS A TOP PRIORITY. The company encourages employees to remain up-to-date on their COVID-19 vaccinations. Rejuvenate Bio, Inc. employees may be required, in the future, to be vaccinated or have an approved disability/medical or religious accommodation.