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Application Scientist

Repligen

Application Scientist

Los Angeles, CA +1 location
Full Time
Paid
  • Responsibilities

    Job Description

    Primary responsibilities include:

    • Development of mammalian cell culture at the bench scale (2-10 L).
    • Execute studies to support new product development testing.
    • Develop protocols and reports for processes in shake flasks, stirred tank and single-use bioreactors using ATF/TFF and other perfusion systems.
    • Analyze and trouble-shoot cell culture processes by monitoring cell growth, viability, protein productivity and other cell culture metabolites.
    • Design experimental plans, scale-up processes.
    • Analyze experimental data, new findings, and literature review.
    • Submit technical reports and give presentations internally and at scientific conferences.
    • Work with other departments including R&D, field applications and sales to accomplish individual and company objectives.

    Qualifications

    • Minimum BS or MS in cell biology, chemical engineering, biochemistry, and related field with experience in mammalian cell culture (2+ years).

    • Experience with cell counters and metabolites analyzers preferred.

    • Previous hands-on experience with shaker flasks and bench scale bioreactors is required.

    • Knowledge of aseptic techniques, cell culture processes, and protein analytics

    • Expertise in setting up lab and pilot scale bioreactors, culturing cells and optimizing feeding and perfusion strategies.

    • Strong analytical and problem-solving skills to understand and to contribute with novel solutions.

    • The ability to work independently and within multidisciplinary project teams.

    • Excellent oral and written communication abilities and strong interpersonal skills to communicate with internal and external team members.

    • Understanding of membrane-based filtration including hollow fiber is a plus

    • Must be able to life 25 pounds on occasion.

    • Must be able to work in a laboratory environment

    Company Description

    Inspiring advances in bioprocessing, Repligen is a leader in bioprocess filtration, pre-packed chromatography and Protein A ligands development. Propelled by a culture of innovation and collaboration, and with a focus on cost and process efficiencies, our people and our technologies help meet critical bioproduction demands worldwide. Named one of the fastest growing biotech companies in the USA, Repligen is headquartered in Waltham, Massachusetts with major manufacturing sites in Massachusetts, California, Sweden, and Germany. This job is located at our CA site in Rancho Dominguez. Repligen offers the broadest range of hollow fiber and flat sheet filtration technologies for cell culture and purification, featuring XCell® ATF Systems, Spectrum® KrosFlo TFF Filters and Systems and TangenX® Flat Sheet TFF Cassettes. As the expert in pre-packed chromatography technology, Repligen offers OPUS® Pre-packed Columns with unparalleled flexibility and scalability from bench- to production-scale. Since 1985, Protein A affinity ligands manufactured by Repligen have been routinely used to purify most of the world’s monoclonal antibodies.

  • Locations
    Los Angeles, CA • Long Beach, CA