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Postdoctoral Associate (Immunity and Pathogenesis) Chanda Lab

Sanford Burnham Prebys Medical Discovery Institute

Postdoctoral Associate (Immunity and Pathogenesis) Chanda Lab

La Jolla, CA
Full Time
Paid
  • Responsibilities

    _Sanford Burnham Prebys is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease, and advancing scientific discoveries to profoundly impact human health. _

    A POSTDOCTORAL ASSOCIATE position is immediately available in the Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program focused on using a systems-level understanding of innate immunity, immunology and virus-host interactions to discover drug targets and small molecule agonists or inhibitors. This position will be focused on generating new technologies and systems for high throughput functional genetic level and small molecule screens. The person filling this position will play an important intellectual, technical, and scientific role in leading projects focused on elucidating novel druggable factors involved in the interplay between virus and host innate immune factors, and understanding their therapeutic implications in inflammatory, autoimmune, infectious disease, and cancer. So far studies within the lab integrate both large-scale technologies (RNAi, AP-MS, NextGen Sequencing, etc.) and more traditional cell & molecular biology and biochemistry-based approaches. Position is supported by NIH funding.

    TO APPLY: Interested candidates should apply online to the SBP career site by submitting one PDF document with a cover letter, CV, references and list of any publications or accomplishments. 

    The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions. Viruses are obligate pathogens, and therefore their survival is dependent upon their ability to exploit host cellular machinery. Concurrently, viruses must also successfully evade immune surveillance mechanisms, including first-line (innate) defense systems. Specifically, we are studying cellular proteins required for both influenza A and retrovirus/HIV infection. additionally, we are investigating novel molecules that regulate, or respond to, Pattern Recognition Receptor (PRR) signaling. Taken together, we aim to elucidate the repertoire of host proteins required for viral infection, and understand the molecular strategies adapted by these viruses as countermeasures to innate immune responses. The scientists in the Chanda lab are also looking to find known drugs that can inhibit the Covid-19 virus. The approach they are taking, known as drug repositioning, can cut development time dramatically. Since they are looking at FDA-approved drugs that are proven to be safe in humans, these medicines could rapidly get to people infected with the virus. If successful, drug repositioning will likely be the fastest path to find a therapeutic solution for the virus. Visit the Chanda lab website to learn more: The Chanda Lab

    VIEW THESE VIDEOS AND LINKS ON THE CURRENT RESEARCH IN THE CHANDA LAB: 

    DISCOVERY OF SARS-COV-2 ANTIVIRAL DRUGS (NATURE)

    COVID-19 ANTIBODY RESEARCH EFFORTS

    MEET SCIENTISTS ON THE FRONT LINE WITH CORONAVIRUS

    FINDING A DRUG FOR COVID-19

    10 NEWS SUMIT CHANDA INTERVIEW

    HIV FUNCTIONAL CURE

    Primary Responsibilities

    • Independently design and perform experiments and procedures with high degree of complexity, demonstrating increasing expertise with a wide range of techniques
    • Demonstrate flexibility in adapting methods and skills according to evolving project priorities
    • Provide independent experimental design and planning
    • Be able to analyze and interpret data from different sources and draw relevant conclusions
    • Demonstrate knowledge in relevant specialized disciplines
    • Be able to present results at internal and external meetings
    • Accurately document experiments
    • Contribute to writing of reports and manuscripts with increasing responsibility over time
    • Work collaboratively across lab functions and train other junior lab staff as needed

     

    Required Skills Required Experience

    • Ph.D. degree in Science is required
    • Strong background in immunology, cell biology, and biochemistry is preferred
    • Experience in functional genomics
    • BSL-3 experience is a must

    Knowledge, Skills and/or Abilities

    • The ability to work independently and to handle multiple projects and deadlines
    • Demonstrated ability to work in an interactive and collaborative team
    • Excellent presentation, verbal, and written communication skills
    • Possess strong attention to detail, analytical, time management, organizational, and interpersonal skills
    • Embody the Institute's core values of Commitment, Collaboration, Communication, Community and Compassion

    The scientists at Sanford Burnham Prebys Medical Discovery Institute are making research breakthroughs in cancer, neuroscience, immunology, and children's disease. We are also at the forefront of finding solutions for emerging health threats such as COVID-19, where we are working to identify drugs that may help millions of people. During our more than 40 year history, we have established an NCI-designated Cancer Center, designed one of the most sophisticated drug discovery centers in the nonprofit world, and created global collaborations that are leading to preventions, treatments and cures to improve human health. 

    Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity Employer – M/F/Veteran/Disability – committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law.  For additional information about your rights as an applicant, click HERE.