Novel epigenetic mechanisms in neurogenesis.

A postdoctoral fellow position is available in the laboratory of Alexey Terskikh, Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California. The position focuses on understanding the role of SoxB1 factors in in self-renewal and differentiation of normal and neoplastic neural stem cell. A candidate will undertake a comprehensive analysis of SoxB1 interactome and function combining the expression analysis, proteome, and chromatin binding assays. Alongside, he or she will investigate at the single cell level the epigenetic landscape in normal neural cell and will interrogate the heterogeneity in primary human brain tumors. The long-term goal of this project is to identify novel genes and pathways implicated in adult neurogenesis and to develop small molecules enhancing adult hippocampal neurogenesis. As a sidetrack of this project we are also interested in small molecules interfering with brain tumor growth and inducing differentiation of cancer “stem cells”.

Skills in tissue culture, cell and molecular biology, fluorescent microscopy, computational biology and writing skills are required.

The candidate must have a Ph.D. degree in any discipline of Biological Sciences.  Experience with transgenic mice model is highly desirable.

Contact Prof. Alexey Terskikh - terskikh@sbpdiscovery.org

Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity employer – M/F/Veteran/Disability – committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law. For additional information about your rights as an applicant, click HERE.

Sanford Burnham Prebys Medical Discovery Institute will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information.