Who we’re looking for:

You are a highly collaborative, talented and motivated medicinal chemist, with a strong understanding of modern synthetic organic chemistry methods. You thrive in a multi-disciplinary team environment and are looking for an opportunity to work alongside leaders in the field of targeted protein degradation, where you are empowered to enable drug discovery programs and explore new aspects of this emerging and compelling science.

Role and responsibilities:

Contribute to projects as a synthetic and medicinal chemist aiding in driving projects from inception, through hit finding and lead optimization, to candidate selection and clinical development.

• In this lab-based role, you will impact from the bench through designing and executing multistep syntheses of complex small molecules while characterizing intermediates and final products.

• Leverage SAR insights, as well as structure‑ and ligand‑based design techniques, and optimize pharmacological properties

• Be a team player to enable chemistry for project teams and/or generate advanced building blocks for team use.

• Have the opportunity to manage external chemistry resources focusing on problem solving and target prioritization.

• Contribute to patents and scientific publications.

• Work within mandated laboratory safety policies and practices and maintain an electronic notebook to company standards

Requirements:

• Ph.D. in synthetic organic chemistry or related discipline, or M.S. with 5+ years industry experience, or B.S. with 10+ years industry experience.
• Proven ability to design and synthesize high‑impact small molecules that move drug discovery programs toward critical decision points.
• Demonstrated in depth knowledge of modern organic synthetic methods, purification and analytical techniques.
• Demonstrated knowledge of medicinal chemistry including multiparameter optimization efforts.
• The ideal candidate is familiar with both structure and ligand based small molecule optimization paradigms.
• Strong collaboration and communication skills.

What we offer:

• Industry competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Career advancement opportunities
• Monthly town halls to share business and scientific updates

Work Hard, Stay Well

• Comprehensive medical, dental, and vision plans for employees and their dependents
• Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
• Employee Assistance Program
• 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
• Supplemental pay for Pregnancy Disability Leave
• Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care

Lifestyle

• Casual work environment
• Volunteer days off each year to spend time contributing to causes you care about
• Flexible work schedule
• Access to onsite gym
• Onsite space to store your bicycle (or surfboard)

Have Fun!

We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).

About Us:

Neomorph is a clinical-stage biotechnology company pioneering the discovery and development of molecular glue degraders to unlock new therapeutic possibilities across serious diseases. By engineering neomorphic protein surfaces, Neomorph enables precision targeted protein degradation of disease drivers that have historically been considered undruggable.

As a leader in molecular glue technology, Neomorph has created the world’s largest proprietary molecular glue target space, spanning multiple novel degrons across an expansive portfolio of E3 ubiquitin ligases. The company was founded in 2020 and is venture-backed by Deerfield Management Company.

Neomorph is headquartered in San Diego, California.

Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.

Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.