Job Description

We are seeking a scientific contributor to lead and execute in vivo studies using novel LNP formulations designed to cross the BBB and target cells within the brain. This role will spearhead our CNS program and would be responsible for designing and executing in vivo studies using rodent models as well as downstream bioanalytic methods. The candidate would have the opportunity to work in a collaboration-oriented role in which they would coordinate with other teams, plan and run animal studies with a cross-functional group of scientists, and support the growth and career development of junior scientists. The ideal candidate is a life sciences major with strong in-vivo and ex-vivo analytic techniques who is excited by the idea of being a core participant in building an early startup and guiding the scientific vision of the company. They would be engaged in science and driven by our mission to create therapies that help people in ways that are currently impossible.

Key Responsibilities

• Design, plan and execute in vivo experiments to support LNP based targeted delivery across the blood brain barrier through systemic administration
• Develop bioanalytical assays (cell-based, flow cytometry, ELISA, biomedical imaging) to assess the delivery efficiency of RNA cargo in rodent tissue to facilitate development of neuroscience focused therapeutics pipeline
• Conduct studies in small animals models for brain characterization, biodistribution (qualitative/quantitative), disease model development, efficacy and toxicity assessment
• Contribute to patent applications related to the neuroscience program
• Perform CRO outreach including experimental planning, work coordination and data interpretation for neuroscience program
• Support technology transfer to Industry Partners
• Foster collaborative relationships across the team and company and engage in a positive and exciting work environment
• Contribute to hiring, training, and collaborating with scientists (as needed) to support assessment of efficacy in relevant in vivo models
• Plan and coordinate animal studies with formulations team members
• Author technical documents, including SOPs for analytical methods, maintain diligent records and demonstrate proficiency in scientific communication
• Support high-quality documentations to support regulatory filings

Qualifications

Minimum Qualifications:

• PhD/MS in life sciences, pharmaceutical sciences, or related field, preferably with 1-3/6+ years of relevant experience. The title will be commensurate with experience.
• Experience working with murine animals, including animal handling, dosing (IV, IP, PO, SC), blood collection (submandibular and cardiac) and tissue necropsy
• Prior experience in neuroscience focused research is a must
• Knowledge in brain physiology and cell biology
• Experience in biomolecular analytics (ELISA, PCR, Flow Cytometry)
• Must be eligible to work in the United States

Preferred Qualifications:

• Experience in brain tissue dissection, histology and imaging is a plus
• Strong communication skills and ability to present complex technical topics to diverse audiences with varying technical depth.
• Strong collaborative instinct with good time and resource management skills to match the fast-paced start-up work culture.
• Able to collaborate on and execute multiple parallel studies

Additional Information

What We Offer:

At our RNA Venture, we aim to outmatch the typical benefits you might see in an early startup. We offer:

• Financial security through competitive compensation, incentives, and retirement plan
• Health care and well-being programs including competitive medical, dental, vision & medical benefits
• Generous paid time off including vacation, sick time, holidays, and winter shutdown
• 401(k) retirement savings with a generous company match
• Commuter benefits
• Other comprehensive voluntary benefits include but are not limited to pet insurance, life insurance, employee assistance program (EAP), discount programs, and many more
• We continue to optimize our benefits & wellness programs as we grow our organization to make sure they meet our diverse workforce needs
• The stability of a startup backed by a company with a record of strong financial performance year over year