C-Clinical is looking for an experienced Senior Clinical Research Associate to support clinical trials across the Philadelphia region. This opportunity is well-suited for professionals who enjoy working closely with investigative sites while ensuring strong oversight of complex clinical studies. The position includes both remote monitoring and on-site visits, offering a balanced approach that keeps you connected to study teams while maintaining flexibility in your work environment. We are looking for individuals with a strong background in clinical monitoring and meaningful experience within central nervous system indications, such as neurology or psychiatry-related research. This position requires professionals who understand regulatory expectations, communicate effectively with site teams, and maintain a high level of attention to protocol compliance and data integrity. C-Clinical is committed to advancing meaningful research that improves patient outcomes. Our team values collaboration, professionalism, and scientific integrity, and we welcome individuals who take pride in contributing to well-run clinical trials. If you are a Senior CRA based in the greater Philadelphia area with strong CNS monitoring experience and are interested in working within a collaborative clinical research environment, we encourage you to apply. Responsibilities: • Coordinate with study teams to support the successful initiation and execution of clinical trials • Identify, evaluate, and qualify investigators and research sites within the Philadelphia region and surrounding areas • Prepare and review essential documentation required for site initiation and regulatory readiness • Conduct on-site monitoring visits and remote monitoring activities while maintaining detailed documentation of findings and follow-up actions • Collaborate with Clinical Trial Managers and Project Managers to escalate site concerns and resolve operational challenges • Review study data on an ongoing basis to identify discrepancies, missing information, or protocol deviations • Support the full monitoring lifecycle, including pre-study visits, site initiation visits, routine monitoring visits, and close-out visits • Verify that informed consent procedures and protocol requirements are properly followed to protect research participants • Track and follow up on adverse events and serious adverse events while ensuring appropriate reporting procedures are followed • Ensure the accuracy and integrity of case report form data through a comprehensive source document review • Maintain compliance with study monitoring plans, standard operating procedures, and regulatory guidelines • Participate in investigator meetings, project team meetings, and study-related teleconferences • Maintain ongoing training related to ICH GCP, study protocols, and internal procedures • Support regulatory documentation tracking, site performance evaluation, and study timeline adherence Qualifications: • Five or more years of clinical research monitoring experience as a Clinical Research Associate • At least three years of experience supporting studies in central nervous system indications, such as neurology or psychiatry-related therapeutic areas • Minimum four years of experience working in contract-based CRA positions, such as independent contractor, consultant, or similar arrangements • Experience conducting site monitoring visits and managing investigator site relationships • Bachelor’s degree from a four-year university, preferably in a scientific or health-related field • Candidates with significant clinical research experience, nursing background, or relevant medical certifications may be considered in place of a traditional degree • Ability to work as an independent vendor or through an established corporation or LLC with appropriate business insurance • Must have authorization to work in the United States • Must be located within the greater Philadelphia area • Availability to support studies for at least one year • Strong communication skills in English and the ability to navigate complex clinical research discussions using medical terminology • Professional communication skills with the ability to collaborate effectively across study teams and research sites • Clinical research certifications, such as CCRA, CCRP, or similar credentials, are beneficial but not required Compensation: $65 - $90 hourly

• Coordinate with study teams to support the successful initiation and execution of clinical trials • Identify, evaluate, and qualify investigators and research sites within the Philadelphia region and surrounding areas • Prepare and review essential documentation required for site initiation and regulatory readiness • Conduct on-site monitoring visits and remote monitoring activities while maintaining detailed documentation of findings and follow-up actions • Collaborate with Clinical Trial Managers and Project Managers to escalate site concerns and resolve operational challenges • Review study data on an ongoing basis to identify discrepancies, missing information, or protocol deviations • Support the full monitoring lifecycle, including pre-study visits, site initiation visits, routine monitoring visits, and close-out visits • Verify that informed consent procedures and protocol requirements are properly followed to protect research participants • Track and follow up on adverse events and serious adverse events while ensuring appropriate reporting procedures are followed • Ensure the accuracy and integrity of case report form data through a comprehensive source document review • Maintain compliance with study monitoring plans, standard operating procedures, and regulatory guidelines • Participate in investigator meetings, project team meetings, and study-related teleconferences • Maintain ongoing training related to ICH GCP, study protocols, and internal procedures • Support regulatory documentation tracking, site performance evaluation, and study timeline adherence