In this position, you will play a key role in our strain and metabolic engineering efforts. You will engineer the cells that we use as the chassis organisms in our cell-free synthesis platform. Your work will be at the forefront of cell-free protein synthesis research as we engineer strains to produce complex proteins at high titers.
RESPONSIBILITIES
Design, implement, and troubleshoot bacterial strain engineering techniques.
Design and construct microbial strains to optimize production of proteins in cell-free based on understanding of cell metabolism, review of relevant literature, and collaboration with scientific leadership.
Collaborate with our synthetic biology, fermentation, purification, and regulatory teams to design, plan and execute demanding strain engineering and screening campaigns that produce strains to meet bioprocess needs and GMP requirements.
Test the performance of the engineered strains using growth, metabolic, and productivity assays including fermentation, HPLC, ELISA, SDS-PAGE, Western Blotting, etc.
Design and implement screening or selection methods to quickly validate new constructs.
Utilize bioinformatics DNA sequence analyses to design and validate successfully engineered strains.
Interpret and present experimental data to scientific, engineering, and leadership teams.
QUALIFICATIONS