SwiftScale Biologics uses our cell-free protein synthesis platform to enable (1) fast clinical therapeutic scaleup and (2) large-scale synthesis of proteins that are very difficult to express in cells. Our mission is to use our platform technology to enable our partners to advance dozens of novel therapeutics.

In this position, you will play a key role in scaling our novel process from pilot to clinical scale, improving yields, improving process consistency, and conforming our process to GMP regulatory requirements. Our process works on standard bioprocess equipment, including a bioreactor, centrifuge, homogenizer, and AKTA purification system. Specifically, this role will focus on assisting in the development of our protein and plasmid purification processes.

RESPONSIBILITIES

• Assist with the scaling of our protein and plasmid DNA production process from lab to pilot scale to clinical scale by running and supporting experiments involving key unit operations including bioreactor fermentation, lysis, depth filtration tangential flow filtration, and purification.

• Assist with installing and maintaining protein and DNA production and purification equipment.

• Develop, modify, and execute Standard Operating Procedures (SOPs) for protein and plasmid DNA production.

• Perform analytical procedures including HPLC, quantification kits, filtration, sample dilutions, centrifugation, and optical density/turbidity analyses.

• Interpret and present data to team members and senior management to make and inform critical process development choices.

• Ensure department is clean and organized at all times and free of hazards and safety violations, maintain areas in high state of cleanliness and organization.

QUALIFICATIONS

• [Required] BS or MS in Bioengineering, Biology, Biochemistry, Molecular Biology, Biological Engineering, Microbiology, Biomedical Engineering, Biotechnology, Chemical Engineering, or related fields.
• [Preferred] Direct experience with upstream and downstream unit operations (e.g. fermentation, centrifugation, homogenization, protein purification, DNA purification, and tangential flow filtration). Experience in alkaline lysis and chromatography preferred.
• Ability to work in a fast-paced small company environment with a drive to creatively solve problems around how to speed up process development, optimization, and operation while ensuring GLP and GMP compliance.
• Strong attention to detail and experience in aseptic techniques.
• Ability to work as part of a team in a collaborative environment to accomplish the company's goals.
• Availability to work full-time hours at our clinical manufacturing facility in Oakland, CA.
• A drive to creatively solve problems around how to speed up process development, optimization, and operation while ensuring GLP and GMP compliance.
• High intrinsic motivation and a desire to learn new techniques

Our work environment is focused on treating everyone on our team with respect, taking ownership of our work, learning new skills, and having fun.

This is a contract position with competitive compensation and opportunity for renewal.