SBP is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease, and advancing scientific discoveries to profoundly impact human health. For over 40 years, our research has produced breakthroughs in cancer, neuroscience, immunology and children’s diseases, and is anchored by our NCI-designated cancer center and advanced drug discovery capabilities.

SUMMARY

The Terskikh laboratory has a Postdoctoral Associate opening.  This position focuses on the novel approach to study epigenetics at a single cell level. The Postdoc Associate will explore the capability of Microscopic Imaging of Epigenetic Landscape (MIEL) and fluorescence-based reporters enabling live imaging of epigenetic modifications at a single cell level. MIEL combines fluorescence detection of epigenetic marks with automated cell imaging and machine learning to profile and quantify the “epigenetic signatures” of individual cells.  They will investigate the epigenetic heterogeneity at the single cell level and the asymmetry during stem cell division in normal neurogenesis and in brain tumors. One of the long-standing question of this project is to determine whether the outcome of stem cell division is stochastic or deterministic and whether such outcome could be predicted based on the epigenetic signature of the mother cell.

TO APPLY: Interested candidates should apply online to the SBP career site by submitting one PDF document with a cover letter, CV, references and list of any publications or accomplishments. 

Duties and Responsibilities

• Independently design and perform experiments and procedures with high degree of complexity, demonstrating increasing expertise with a wide range of techniques
• Demonstrate flexibility in adapting methods and skills according to evolving project priorities
• Provide independent experimental design and planning
• Be able to analyze and interpret data from different sources and draw relevant conclusions
• Demonstrate knowledge in relevant specialized disciplines
• Be able to present results at internal and external meetings
• Accurately document experiments
• Contribute to writing of reports and manuscripts with increasing responsibility over time
• Work collaboratively across lab functions and train other junior lab staff as needed

Required Skills Required Experience

• Ph.D. degree in any discipline of Biological Sciences is required
• The qualified candidate must have proven experience in one or more of the following areas:  Tissue culture, cell and molecular biology, fluorescent microscopy, and computational biology
• Experience with transgenic mice model is highly desirable

Other Knowledge, Skills and/or Abilities

• The ability to work independently and to handle multiple projects and deadlines
• Demonstrated ability to work in an interactive and collaborative team
• Excellent presentation, verbal, and written communication skills
• Possess strong attention to detail, analytical, time management, organizational, and interpersonal skills
• Embody the Institute's core values of Commitment, Collaboration, Communication, Community and Compassion

Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity employer – M/F/Veteran/Disability – committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law. For additional information about your rights as an applicant, click HERE.

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