Job Description

The Upstream development engineer will work in the upstream process development team to design, execute, and optimize consistent fed-batch cell culture processes to produce quality recombinant proteins through laboratory studies. As part of the team, they will ensure that these processes are predictable, scalable, and controlled using multiple sizes of bioreactors (ambr15, ambr250, and bench-top scale bioreactors). The position will support tech transfer of developed and locked cell culture processes to the pilot team and CMOs.

Roles and Responsibilities:

• Conduct upstream process unit operations, which include cell banking, cell expansion, bioreactor process, optimization, and characterization.
• Work collaboratively within the department as well as cross-functional peers to execute various upstream studies using shake flasks, wave bioreactors, and benchtop bioreactors.
• Use high throughput tools such as AMBR15, AMBR25,0, and Robocolumns as well as analytical tools like cell counters, bioanalyzers to support studies.
• Coordinate with the testing team to submit a large number of study samples, compiling results received, analyzing data using data analysis tools such as Microsoft Excel, JMP, Spotfire etc., as well as summarizing the findings.
• Document experiments using an electronic lab notebook, in addition to supporting technical reports for studies.

Qualifications

Minimum Qualifications:

• Bachelor’s degree in chemistry, biology, pharmacy, or related pharmaceutical science; 2-4 years relevant industry experience OR
• Bachelor’s degree in engineering or related discipline; 0-2 years relevant industry experience OR
• Master’s degree in chemistry, biology, pharmacy, engineering, or related pharmaceutical science; 0-2 years relevant industry experience
• Previous experience working in a biologics laboratory or a GMP manufacturing environment
• Experience with mammalian cell culture and aseptic techniques
• experience with bench-scale bioreactor operation and other instrumentation that supports cell culture, such:
  • Metabolite Analyzers
  • Shake Flasks
  • Cell Culture Plates.
• Authorization to work in the United States indefinitely without restriction or sponsorship

The Ideal Candidate will Have:

• Experience with harvest filtration and chromatographic separations
• Experience optimizing upstream processes or expression conditions
• Familiarity with additional analytical tools or advanced bioreactor systems
• Experience troubleshooting critical issues or problems and resolving routine issues
• Strong communication skills, both verbal and written
• Strength in organization, attention to detail and self-motivation

Additional Information

This position is Full-Time, Monday-Friday, 8:00 a.m. - 5:00 p.m. with overtime as needed and the potential for some off-shift hours as depending on the project. Candidates living within a commutable distance of Lexington, MA, are encouraged to apply.

Excellent full-time benefits include:

• comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays

Eurofins Lancaster Laboratories Professional Scientific Services® (PSS) is a global, award-winning insourcing solution that places our people at our clients’ sites, dedicated to running and managing laboratory services while eliminating headcount, co-employment, and project-management worries.

We infuse our 55-year track record of scientific and laboratory operations expertise, as well as HR and great place to work best practices, to recruit, hire, train, and manage highly qualified scientists to perform laboratory services using our clients’ quality systems and equipment.

To learn more about Eurofins Lancaster Laboratories, please explore our website www.eurofinsus.com.

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.