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Scientist III, Tumor Immunology

Workforce Genetics

Scientist III, Tumor Immunology

Rockville, MD
Paid
  • Responsibilities

    Our client, a leader in discovering and developing innovate antibody-based therapeutics, is seeking an experience SCIENTIST III. In this role, you will contribute to the biological characterization of the Company’s antibody-based oncology product candidates including both pre-clinical and clinical stage programs.

    RESPONSIBILITIES AND JOB DUTIES:

    • Biological characterization of antibody-based therapeutics including multi-specifics. Data will be used to support lead molecule selection, IND and regulatory filings, and guide therapeutic opportunity in clinical setting.
    • Implement and execute immune based assays to characterize mechanism of activation (MoA) and potential combinatorial activity both within and between antibody-based molecules and/or other therapeutic modalities.
    • Apply state of the art of molecular and cellular technologies (inc multi-parameter flow cytometry and NGS) to characterize immune mediated tumor mechanisms Leverage research expertise in fields of innate and adaptive immunity in the tumor microenvironment (eg T-cell biology, TCR signaling, Tregs, MDSCs, TAMs) to discover and dissect novel therapeutic intervention strategies.
    • Participate in multi-functional teams responsible for antibody-based molecules ranging in development stage from early research through clinical development.
    • Provide day-to-day management of direct reports, guiding experimental planning and trouble-shooting, data interpretation and assembly.
    • Coach, mentor and manage people for performance and scientific growth.
    • Draft manuscripts and nonclinical sections for regulatory submission.
    • Provide external visibility through participation in scientific meetings and symposia.

    QUALIFICATIONS

    Education

    Ph.D. or equivalent advanced degree – Immunology, Cell Biology or Biological Science

    Experience

    • Minimum of five years research post PhD
    • Industrial experience in a biotech/pharmaceutical company or equivalent

    Knowledge, Skills and Abilities

    • Expertise in tumor immunology as evidenced by high impact publications
    • Thorough understanding of cell-based assay technologies and experience with animal models for evaluation of immunotherapies
    • Hands-on experience employing immune based assays including multiparameter flow cytometry.
    • Capability in profiling of tumor infiltrate and characterization of functional activity of Tumor Infiltrating Lymphocytes a plus.
    • Capability in leveraging/monitoring immune-cell stimulatory and/or inhibitory activities mediated by molecular entities
    • Proficient in scientific documentation supporting submissions to regulatory agencies
    • An excellent scientific/clinical background as demonstrated through publications in basic medical science journals
    • Strong decision-making, complex problem-solving and critical data analysis and interpretation
    • Innovative with the ability to multi-task
    • Excellent written and verbal communication skills

    SUPERVISORY RESPONSIBILITIES

    Research Associate