Benefits:
401(k)
Bonus based on performance
Competitive salary
Dental insurance
Health insurance
Paid time off
Parental leave
Stock options plan
Vision insurance
Opportunity for advancement
Zag Bio’s vision is to develop more precise, potent medicines for immune-mediated diseases. Zag Bio is pioneering engineered antibody therapies targeted directly to the thymus, with the goal of generating central tolerance. Our technology platform is inspired by the work of co-founder Diane Mathis of Harvard Medical School; additional co-founders include Alan Crane (Polaris Partners), Jo Viney (Seismic Therapeutic), and John Kulman (Zag Bio). Zag Bio is a stealth stage biotech company, poised for growth in line with our ambition to transform the treatment of immune-mediated diseases.
We are seeking an experienced Immunologist to oversee the execution and development of in vivo models in support of advancement of the company’s novel therapeutics platform for autoimmune disease. This role will require a high level of collaboration with colleagues on the therapeutic and platform development teams.
RESPONSIBILITIES:
In this role, you will report to the Director of Immunology and integrally contribute to determining the mechanisms of action of novel thymus-directed therapeutics. You will apply your creativity and foundational background in immunology to the development of novel therapeutics for autoimmune diseases to:
Formulate hypotheses, design and implement immunological assays and models, and evaluate results to elucidate therapeutic mechanism of action.
Serve as the subject matter expert for murine pharmacology models; develop and execute project plans as part of a collaborative cross-functional team.
Prepare and interpret various scientific data to present to Leadership, in team and company meetings.
Support, train, coach and mentor the lab team.
Author research reports and relevant sections of regulatory documents to support first-in-human studies and contribute to intellectual property filings.
Document research activities and findings in electronic laboratory notebook and reagent registries in keeping with the highest industry standards.
REQUIREMENTS:
Ph.D. in Immunology or related field with a minimum of 2 years of industry or academic (post-doctoral) experience or a B.S./M.S. and 10+ years of highly relevant industry experience. Title will be based on relevant qualifications.
Proficiency with in vivo procedures, including injections (IV, SC, IP), blood/tissue collection, etc.
Experience in isolating and characterizing immune cells ex vivo using multiparametric approaches such as immunophenotyping, functional assays, genomics profiling, etc.
Ability to effectively manage multiple projects in a fast-paced environment.
Excellent communication and interpersonal skills, and the ability to thrive in a dynamic cross-functional environment.
PREFERRED EXPERIENCE:
Mouse autoimmune/inflammatory disease models and/or development of novel PK/PD models.
Approaches to monitor antigen-specific T cell activity is highly desirable.
The application of single cell genomics methods to understanding immune cell biology.
Drug discovery and preclinical drug development practices from discovery to IND.
Zag Bio values the diversity of our workforce and maintains a deeply respectful, values-driven working environment. We are committed to equal employment opportunities and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation, or any characteristic protected under applicable law.
We are not accepting unsolicited resumes from employment agencies for any employment opportunities at this time.